Diffuse large B-cell lymphoma can develop from which precursor condition?

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Multiple Choice

Diffuse large B-cell lymphoma can develop from which precursor condition?

Explanation:
DLBCL is an aggressive B-cell lymphoma that can arise not only on its own but also by transformation from an indolent B-cell lymphoma, most classically follicular lymphoma. In transformation, the disease gains additional genetic changes that shift it from a slower, follicular growth pattern to a diffuse, high-grade proliferation of large B cells, leading to rapid clinical progression. This makes the statement that it can develop from follicular lymphoma the best answer. It isn’t the least common NHL, and while some DLBCL tumors are EBV-positive, many are EBV-negative, and the disease is of B-cell origin, not T-cell.

DLBCL is an aggressive B-cell lymphoma that can arise not only on its own but also by transformation from an indolent B-cell lymphoma, most classically follicular lymphoma. In transformation, the disease gains additional genetic changes that shift it from a slower, follicular growth pattern to a diffuse, high-grade proliferation of large B cells, leading to rapid clinical progression. This makes the statement that it can develop from follicular lymphoma the best answer. It isn’t the least common NHL, and while some DLBCL tumors are EBV-positive, many are EBV-negative, and the disease is of B-cell origin, not T-cell.

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