First-line treatment for severe hypertriglyceridemia is which agent?

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Multiple Choice

First-line treatment for severe hypertriglyceridemia is which agent?

Explanation:
Fibrates are the first-line therapy for severe hypertriglyceridemia because they activate PPAR-α, which increases lipoprotein lipase activity and decreases hepatic VLDL production. This combination markedly lowers triglyceride-rich lipoproteins in the blood, reducing the risk of pancreatitis associated with very high triglycerides. Niacin also lowers triglycerides but is less favored due to tolerability and side-effect concerns; statins mainly reduce LDL cholesterol with only modest TG reduction; bile acid sequestrants primarily lower LDL and can sometimes raise triglycerides.

Fibrates are the first-line therapy for severe hypertriglyceridemia because they activate PPAR-α, which increases lipoprotein lipase activity and decreases hepatic VLDL production. This combination markedly lowers triglyceride-rich lipoproteins in the blood, reducing the risk of pancreatitis associated with very high triglycerides. Niacin also lowers triglycerides but is less favored due to tolerability and side-effect concerns; statins mainly reduce LDL cholesterol with only modest TG reduction; bile acid sequestrants primarily lower LDL and can sometimes raise triglycerides.

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