Placental alkaline phosphatase is a marker associated with which tumor?

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Multiple Choice

Placental alkaline phosphatase is a marker associated with which tumor?

Explanation:
Placental alkaline phosphatase is a placental-type enzyme that serves as a useful immunohistochemical marker for germ cell tumors, especially seminoma. In seminoma cells, PLAP expression is typically strong and diffuse, helping distinguish this tumor from other testicular neoplasms and from non-seminomatous germ cell tumors that often lack PLAP or show only focal staining. While PLAP can be seen in dysgerminoma of the ovaries, it is not a hallmark of osteosarcoma, hepatocellular carcinoma, or lymphoma, which usually do not express PLAP. Thus, this marker is most closely associated with seminoma.

Placental alkaline phosphatase is a placental-type enzyme that serves as a useful immunohistochemical marker for germ cell tumors, especially seminoma. In seminoma cells, PLAP expression is typically strong and diffuse, helping distinguish this tumor from other testicular neoplasms and from non-seminomatous germ cell tumors that often lack PLAP or show only focal staining. While PLAP can be seen in dysgerminoma of the ovaries, it is not a hallmark of osteosarcoma, hepatocellular carcinoma, or lymphoma, which usually do not express PLAP. Thus, this marker is most closely associated with seminoma.

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